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Lysosomal adaptation: How cells respond to lysosomotropic compounds

Lysosomes are acidic organelles essential for degradation and cellular homoeostasis and recently lysosomes have been shown as signaling hub to respond to the intra and extracellular changes (e.g. amino acid availability). Compounds including pharmaceutical drugs that are basic and lipophilic will be...

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Detalles Bibliográficos
Autores principales: Lu, Shuyan, Sung, Tae, Lin, Nianwei, Abraham, Robert T., Jessen, Bart A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354416/
https://www.ncbi.nlm.nih.gov/pubmed/28301521
http://dx.doi.org/10.1371/journal.pone.0173771