Restored mutant receptor:Corticoid binding in chaperone complexes by trimethylamine N-oxide

Without a glucocorticoid (GC) ligand, the transcription factor glucocorticoid receptor (GR) is largely cytoplasmic, with its GC-binding domain held in high affinity conformation by a cluster of chaperones. Binding a GC causes serial dis- and re-associations with chaperones, translocation of the GR t...

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Detalles Bibliográficos
Autores principales: Miller, Aaron L., Elam, W. Austin, Johnson, Betty H., Khan, Shagufta H., Kumar, Raj, Thompson, E. Brad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354453/
https://www.ncbi.nlm.nih.gov/pubmed/28301576
http://dx.doi.org/10.1371/journal.pone.0174183

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354453/
https://www.ncbi.nlm.nih.gov/pubmed/28301576
http://dx.doi.org/10.1371/journal.pone.0174183

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