Targeted Fcγ Receptor (FcγR)-mediated Clearance by a Biparatopic Bispecific Antibody

Soluble ligands have commonly been targeted by antibody therapeutics for cancers and other diseases. Although monoclonal antibodies targeting such ligands can block their interactions with their cognate receptors, they can also significantly increase the half-life of their ligands by FcRn-mediated a...

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Detalles Bibliográficos
Autores principales: Kasturirangan, Srinath, Rainey, G. Jonah, Xu, Linda, Wang, Xinwei, Portnoff, Alyse, Chen, Tracy, Fazenbaker, Christine, Zhong, Helen, Bee, Jared, Zeng, Zhutian, Jenne, Craig, Wu, Herren, Gao, Changshou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354496/
https://www.ncbi.nlm.nih.gov/pubmed/28100773
http://dx.doi.org/10.1074/jbc.M116.770628

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354496/
https://www.ncbi.nlm.nih.gov/pubmed/28100773
http://dx.doi.org/10.1074/jbc.M116.770628

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