Induction of erythropoiesis by hypoxia-inducible factor prolyl hydroxylase inhibitors without promotion of tumor initiation, progression, or metastasis in a VEGF-sensitive model of spontaneous breast cancer

The effects of pharmacological hypoxia-inducible factor (HIF) stabilization were investigated in the MMTV-Neu(ndl)-YD5 (NeuYD) mouse model of breast cancer. This study first confirmed the sensitivity of this model to increased vascular endothelial growth factor (VEGF), using bigenic NeuYD;MMTV-VEGF-...

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Detalles Bibliográficos
Autores principales: Seeley, Todd W, Sternlicht, Mark D, Klaus, Stephen J, Neff, Thomas B, Liu, David Y
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354531/
https://www.ncbi.nlm.nih.gov/pubmed/28331872
http://dx.doi.org/10.2147/HP.S130526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354531/
https://www.ncbi.nlm.nih.gov/pubmed/28331872
http://dx.doi.org/10.2147/HP.S130526

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