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Can the HIV-1 splicing machinery be targeted for drug discovery?
HIV-1 is able to express multiple protein types and isoforms from a single 9 kb mRNA transcript. These proteins are also expressed at particular stages of viral development, and this is achieved through the control of alternative splicing and the export of these transcripts from the nucleus. The nuc...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Dove Medical Press
2017
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354533/ https://www.ncbi.nlm.nih.gov/pubmed/28331370 http://dx.doi.org/10.2147/HIV.S120576 |