Insights into cytochrome bc (1) complex binding mode of antimalarial 2-hydroxy-1,4-naphthoquinones through molecular modelling

BACKGROUND: Malaria persists as a major public health problem. Atovaquone is a drug that inhibits the respiratory chain of Plasmodium falciparum, but with serious limitations like known resistance, low bioavailability and high plasma protein binding. OBJECTIVES: The aim of this work was to perform m...

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Detalles Bibliográficos
Autores principales: Sodero, Ana Carolina Rennó, Abrahim-Vieira, Bárbara, Torres, Pedro Henrique Monteiro, Pascutti, Pedro Geraldo, Garcia, Célia RS, Ferreira, Vitor Francisco, da Rocha, David Rodrigues, Ferreira, Sabrina Baptista, Silva, Floriano Paes
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto Oswaldo Cruz, Ministério da Saúde 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354616/
https://www.ncbi.nlm.nih.gov/pubmed/28327793
http://dx.doi.org/10.1590/0074-02760160417

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354616/
https://www.ncbi.nlm.nih.gov/pubmed/28327793
http://dx.doi.org/10.1590/0074-02760160417

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