Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast

RNA Polymerase II pauses and backtracks during transcription, with many consequences for gene expression and cellular physiology. Here, we show that the energy required to melt double-stranded nucleic acids in the transcription bubble predicts pausing in Saccharomyces cerevisiae far more accurately...

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Detalles Bibliográficos
Autores principales: Lukačišin, Martin, Landon, Matthieu, Jajoo, Rishi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354634/
https://www.ncbi.nlm.nih.gov/pubmed/28301878
http://dx.doi.org/10.1371/journal.pone.0174066

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354634/
https://www.ncbi.nlm.nih.gov/pubmed/28301878
http://dx.doi.org/10.1371/journal.pone.0174066

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