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Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast
RNA Polymerase II pauses and backtracks during transcription, with many consequences for gene expression and cellular physiology. Here, we show that the energy required to melt double-stranded nucleic acids in the transcription bubble predicts pausing in Saccharomyces cerevisiae far more accurately...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354634/ https://www.ncbi.nlm.nih.gov/pubmed/28301878 http://dx.doi.org/10.1371/journal.pone.0174066 |