Hsp90 N- and C-terminal double inhibition synergistically suppresses Bcr-Abl-positive human leukemia cells

Heat shock protein 90 (Hsp90) contains amino (N)–terminal domain, carboxyl(C)-terminal domain, and middle domains, which activate Hsp90 chaperone function cooperatively in tumor cells. One terminal occupancy might influence another terminal binding with inhibitor. The Bcr-Abl kinase is one of the Hs...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Chun, Zhuang, Yingting, Chen, Xianling, Chen, Xiaole, Li, Ding, Fan, Yingjuan, Xu, Jianhua, Chen, Yuanzhong, Wu, Lixian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354638/
https://www.ncbi.nlm.nih.gov/pubmed/28036294
http://dx.doi.org/10.18632/oncotarget.14324

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354638/
https://www.ncbi.nlm.nih.gov/pubmed/28036294
http://dx.doi.org/10.18632/oncotarget.14324

Ejemplares similares