Genetic disruption of the pH(i)-regulating proteins Na(+)/H(+) exchanger 1 (SLC9A1) and carbonic anhydrase 9 severely reduces growth of colon cancer cells

Hypoxia and extracellular acidosis are pathophysiological hallmarks of aggressive solid tumors. Regulation of intracellular pH (pH(i)) is essential for the maintenance of tumor cell metabolism and proliferation in this microenvironment and key proteins involved in pH(i) regulation are of interest fo...

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Detalles Bibliográficos
Autores principales: Parks, Scott K., Cormerais, Yann, Durivault, Jerome, Pouyssegur, Jacques
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354654/
https://www.ncbi.nlm.nih.gov/pubmed/28055960
http://dx.doi.org/10.18632/oncotarget.14379

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354654/
https://www.ncbi.nlm.nih.gov/pubmed/28055960
http://dx.doi.org/10.18632/oncotarget.14379

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