Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels

The molecular mechanisms underlying the anti-breast cancer effects of polyphyllin I, a natural compound extracted from Paris polyphylla rhizomes, are not fully understood. In the present study, we found that polyphyllin I induces mitochondrial translocation of DRP1 by dephosphorylating DRP1 at Ser63...

Descripción completa

Detalles Bibliográficos
Autores principales: Li, Guo-Bing, Fu, Ruo-Qiu, Shen, Han-Ming, Zhou, Jing, Hu, Xiao-Ye, Liu, Yan-Xia, Li, Yu-Nong, Zhang, Hong-Wei, Liu, Xin, Zhang, Yan-Hao, Huang, Cheng, Zhang, Rong, Gao, Ning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354664/
https://www.ncbi.nlm.nih.gov/pubmed/28060722
http://dx.doi.org/10.18632/oncotarget.14413

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354664/
https://www.ncbi.nlm.nih.gov/pubmed/28060722
http://dx.doi.org/10.18632/oncotarget.14413

Ejemplares similares