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Polyphyllin I induces mitophagic and apoptotic cell death in human breast cancer cells by increasing mitochondrial PINK1 levels

The molecular mechanisms underlying the anti-breast cancer effects of polyphyllin I, a natural compound extracted from Paris polyphylla rhizomes, are not fully understood. In the present study, we found that polyphyllin I induces mitochondrial translocation of DRP1 by dephosphorylating DRP1 at Ser63...

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Detalles Bibliográficos
Autores principales:	Li, Guo-Bing, Fu, Ruo-Qiu, Shen, Han-Ming, Zhou, Jing, Hu, Xiao-Ye, Liu, Yan-Xia, Li, Yu-Nong, Zhang, Hong-Wei, Liu, Xin, Zhang, Yan-Hao, Huang, Cheng, Zhang, Rong, Gao, Ning
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354664/ https://www.ncbi.nlm.nih.gov/pubmed/28060722 http://dx.doi.org/10.18632/oncotarget.14413

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