Blockade of the malignant phenotype by β-subunit selective noncovalent inhibition of immuno- and constitutive proteasomes

A structure-based virtual screening of over 400,000 small molecules against the constitutive proteasome activity followed by in vitro assays led to the discovery of a family of proteasome inhibitors with a sulfonyl piperazine scaffold. Some members of this family of small non-peptidic inhibitors wer...

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Detalles Bibliográficos
Autores principales: Villoutreix, Bruno O., Khatib, Abdel-Majid, Cheng, Yan, Miteva, Maria A., Maréchal, Xavier, Vidal, Joëlle, Reboud-Ravaux, Michèle
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354670/
https://www.ncbi.nlm.nih.gov/pubmed/28060729
http://dx.doi.org/10.18632/oncotarget.14428

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354670/
https://www.ncbi.nlm.nih.gov/pubmed/28060729
http://dx.doi.org/10.18632/oncotarget.14428

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