Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress

Colorectal cancers with mutant RAS/RAF are therapy refractory. Deregulated mRNA translation has become an emerging target in cancer treatment. We recently reported that mTOR inhibitors induce apoptosis via ER stress and the extrinsic pathway upon acute inhibition of the eIF4F complex in colon cancer...

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Detalles Bibliográficos
Autores principales: Li, Xiangyun, Li, Mei, Ruan, Hang, Qiu, Wei, Xu, Xiang, Zhang, Lin, Yu, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354731/
https://www.ncbi.nlm.nih.gov/pubmed/28030835
http://dx.doi.org/10.18632/oncotarget.14063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354731/
https://www.ncbi.nlm.nih.gov/pubmed/28030835
http://dx.doi.org/10.18632/oncotarget.14063

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