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Co-targeting translation and proteasome rapidly kills colon cancer cells with mutant RAS/RAF via ER stress
Colorectal cancers with mutant RAS/RAF are therapy refractory. Deregulated mRNA translation has become an emerging target in cancer treatment. We recently reported that mTOR inhibitors induce apoptosis via ER stress and the extrinsic pathway upon acute inhibition of the eIF4F complex in colon cancer...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2016
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354731/ https://www.ncbi.nlm.nih.gov/pubmed/28030835 http://dx.doi.org/10.18632/oncotarget.14063 |