Cargando…

Melatonin protects against arsenic trioxide-induced liver injury by the upregulation of Nrf2 expression through the activation of PI3K/AKT pathway

Melatonin has been demonstrated to have anti-inflammatory and antioxidant effects. The aim of this study was to investigate the protective effects of melatonin on arsenic trioxide (As(2)O(3))-induced toxicity in liver and oxidative stress in rats. The rats were injected with 3mg/kg As(2)O(3) on alte...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhang, Yue, Wei, Zhengkai, Liu, Weijian, Wang, Jingjing, He, Xuexiu, Huang, Hailong, Zhang, Jiali, Yang, Zhengtao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper: Pathology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354794/ https://www.ncbi.nlm.nih.gov/pubmed/27980225 http://dx.doi.org/10.18632/oncotarget.13931

Ejemplares similares

Alpinetin attenuates inflammatory responses by suppressing TLR4 and NLRP3 signaling pathways in DSS-induced acute colitis
por: He, Xuexiu, et al.
Publicado: (2016)

Kaempferol-induced GPER upregulation attenuates atherosclerosis via the PI3K/AKT/Nrf2 pathway
por: Feng, Zhuo, et al.
Publicado: (2021)

Inhibition of angiogenesis by arsenic trioxide via TSP-1–TGF-β1-CTGF–VEGF functional module in rheumatoid arthritis
por: Zhang, Juan, et al.
Publicado: (2017)

Eriodictyol attenuates arsenic trioxide-induced liver injury by activation of Nrf2
por: Xie, Guanghong, et al.
Publicado: (2017)

Magnolol Prevents Acute Alcoholic Liver Damage by Activating PI3K/Nrf2/PPARγ and Inhibiting NLRP3 Signaling Pathway
por: Liu, Xiao, et al.
Publicado: (2019)

The PI3K-AKT-mTOR pathway activates recovery from general anesthesia
por: Zhang, Yun-Hui, et al.
Publicado: (2016)

Melatonin enhances arsenic trioxide-induced cytotoxicity by modulating autophagy in an acute promyelocytic leukemia cell line
por: Wei, Xia, et al.
Publicado: (2019)

Inhibition of early T cell cytokine production by arsenic trioxide occurs independently of Nrf2
por: VanDenBerg, Kelly R., et al.
Publicado: (2017)

Comparison of the Effects of TheraCal LC and Mineral Trioxide Aggregate on Direct Pulp Capping (DPC) Based on Histological Findings
por: Zeater, Basel, et al.
Publicado: (2022)

Arsenic Trioxide and Venetoclax Synergize against AML Progenitors by ROS Induction and Inhibition of Nrf2 Activation
por: Hoang, Dinh Hoa, et al.
Publicado: (2022)

Vorinostat enhances chemosensitivity to arsenic trioxide in K562 cell line
por: Li, Nainong, et al.
Publicado: (2015)

Sulforaphane potentially attenuates arsenic-induced nephrotoxicity via the PI3K/Akt/Nrf2 pathway in albino Wistar rats
por: Thangapandiyan, Shanmugam, et al.
Publicado: (2019)

Melatonin ameliorates ANIT-induced cholestasis by activating Nrf2 through a PI3K/Akt-dependent pathway in rats
por: Li, Yunzhou, et al.
Publicado: (2019)

In silico mechanisms of arsenic trioxide-induced cardiotoxicity
por: Li, Yacong, et al.
Publicado: (2022)

VEGFA Expression Is Inhibited by Arsenic Trioxide in HUVECs through the Upregulation of Ets-2 and miRNA-126
por: Ge, Hong-yan, et al.
Publicado: (2015)

miR-155 mediates arsenic trioxide resistance by activating Nrf2 and suppressing apoptosis in lung cancer cells
por: Gu, Shiyan, et al.
Publicado: (2017)

Targeting Catalase but Not Peroxiredoxins Enhances Arsenic Trioxide-Induced Apoptosis in K562 Cells
por: Song, Li-Li, et al.
Publicado: (2014)

Edaravone and Acetovanillone Upregulate Nrf2 and PI3K/Akt/mTOR Signaling and Prevent Cyclophosphamide Cardiotoxicity in Rats
por: Hassanein, Emad H M, et al.
Publicado: (2020)

On arsenic trioxide in the clinical treatment of acute promyelocytic leukemia
por: Zhang, Peng
Publicado: (2017)

Effects of arsenic trioxide on the expression of ezrin in hepatocellular carcinoma
por: Lu, Wei, et al.
Publicado: (2017)

Effect of arsenic trioxide on cervical cancer and its mechanisms
por: Zhang, Liping, et al.
Publicado: (2020)

Evidences of Protective Potentials of Microdoses of Ultra-High Diluted Arsenic Trioxide in Mice Receiving Repeated Injections of Arsenic Trioxide
por: Banerjee, Pathikrit, et al.
Publicado: (2011)

Insulin upregulates betatrophin expression via PI3K/Akt pathway
por: Lu, Puhan, et al.
Publicado: (2017)

Arsenic trioxide as an inducer of immunogenic cell death
por: Kepp, Oliver, et al.
Publicado: (2023)

Immunological consequences of arsenic trioxide-induced necrosis
por: Gavali, Shubhangi, et al.
Publicado: (2023)

Retracted: Evidences of Protective Potentials of Microdoses of Ultra-High Diluted Arsenic Trioxide in Mice Receiving Repeated Injections of Arsenic Trioxide
por: Medicine, Evidence-Based Complementary and Alternative
Publicado: (2021)

TRAIL sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and Akt
por: Szegezdi, E, et al.
Publicado: (2006)

The Protective Role of Resveratrol against Arsenic Trioxide-Induced Cardiotoxicity
por: Zhang, Weiqian, et al.
Publicado: (2013)

Bone marrow stroma-induced resistance of chronic lymphocytic leukemia cells to arsenic trioxide involves Mcl-1 upregulation and is overcome by inhibiting the PI3Kδ or PKCβ signaling pathways
por: Amigo-Jiménez, Irene, et al.
Publicado: (2015)

Protective effect of resveratrol on arsenic trioxide-induced nephrotoxicity in rats
por: Zhang, Weiqian, et al.
Publicado: (2014)

Olive: A Potential Suppressor for Cervical Cancer by Upregulation of P21
por: Patel, Love, et al.
Publicado: (2023)

Shikonin potentiates the effect of arsenic trioxide against human hepatocellular carcinoma in vitro and in vivo
por: Song, Jingjing, et al.
Publicado: (2016)

The NRF2-mediated oxidative stress response pathway is associated with tumor cell resistance to arsenic trioxide across the NCI-60 panel
por: Liu, Qian, et al.
Publicado: (2010)

PI3K/Akt/mTOR Signaling Pathway and the Biphasic Effect of Arsenic in Carcinogenesis
por: Chen, Qiao Yi, et al.
Publicado: (2018)

Skp2 Expression Is Inhibited by Arsenic Trioxide through the Upregulation of miRNA-330-5p in Pancreatic Cancer Cells
por: Gao, Jiankun, et al.
Publicado: (2019)

Nrf2 Negatively Regulates Melanogenesis by Modulating PI3K/Akt Signaling
por: Shin, Jung-Min, et al.
Publicado: (2014)

Oxidative stress induced by the chemotherapeutic agent arsenic trioxide
por: Varghese, Mathews V., et al.
Publicado: (2013)

Arsenic Trioxide Sensitizes Glioblastoma to a Myc Inhibitor
por: Yoshimura, Yayoi, et al.
Publicado: (2015)

A Review of Arsenic Trioxide and Acute Promyelocytic Leukemia
por: Alimoghaddam, Kamran
Publicado: (2014)

Modulation of Cellular Response to Arsenic Trioxide Toxicity by Resveratrol
por: Mondal, Bodhisattwa, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_aj2uk5j68q1623vtbm5n4auu0t