LSD1 mediates MYCN control of epithelial-mesenchymal transition through silencing of metastatic suppressor NDRG1 gene

Neuroblastoma (NB) with MYCN amplification is a highly aggressive and metastatic tumor in children. The high recurrence rate and resistance of NB cells to drugs urgently demands a better therapy for this disease. We have recently found that MYCN interacts with the lysine-specific demethylase 1 (LSD1...

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Detalles Bibliográficos
Autores principales: Ambrosio, Susanna, Amente, Stefano, Saccà, Carmen D., Capasso, Mario, Calogero, Raffaele A., Lania, Luigi, Majello, Barbara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354800/
https://www.ncbi.nlm.nih.gov/pubmed/27894074
http://dx.doi.org/10.18632/oncotarget.12924

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354800/
https://www.ncbi.nlm.nih.gov/pubmed/27894074
http://dx.doi.org/10.18632/oncotarget.12924

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