Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation

PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β (encoded by PIK3CB) activity but little is known about this contribution in endome...

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Detalles Bibliográficos
Autores principales: Karlsson, Thomas, Krakstad, Camilla, Tangen, Ingvild Løberg, Hoivik, Erling A., Pollock, Pamela M., Salvesen, Helga B., Lewis, Aurélia E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354802/
https://www.ncbi.nlm.nih.gov/pubmed/28002804
http://dx.doi.org/10.18632/oncotarget.13989

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354802/
https://www.ncbi.nlm.nih.gov/pubmed/28002804
http://dx.doi.org/10.18632/oncotarget.13989

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