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Endometrial cancer cells exhibit high expression of p110β and its selective inhibition induces variable responses on PI3K signaling, cell survival and proliferation

PTEN loss and constitutive activation of the class I phosphoinositide 3-kinase (PI3K) pathway are key drivers of endometrial tumorigenesis. In some cancer types, PTEN-deficient tumors are reliant on class I PI3K p110β (encoded by PIK3CB) activity but little is known about this contribution in endome...

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Detalles Bibliográficos
Autores principales:	Karlsson, Thomas, Krakstad, Camilla, Tangen, Ingvild Løberg, Hoivik, Erling A., Pollock, Pamela M., Salvesen, Helga B., Lewis, Aurélia E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354802/ https://www.ncbi.nlm.nih.gov/pubmed/28002804 http://dx.doi.org/10.18632/oncotarget.13989

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