Cargando…

The JAZF1-SUZ12 fusion protein disrupts PRC2 complexes and impairs chromatin repression during human endometrial stromal tumorogenesis

The Polycomb repressive complex 2 (PRC2), which contains three core proteins EZH2, EED and SUZ12, controls chromatin compaction and transcription repression through trimethylation of lysine 27 on histone 3. The (7;17)(p15;q21) chromosomal translocation present in most cases of endometrial stromal sa...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Xianyong, Wang, Jinglan, Wang, Jianhui, Ma, Charles X., Gao, Xiaobin, Patriub, Vytas, Sklar, Jeffrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354813/ https://www.ncbi.nlm.nih.gov/pubmed/27845897 http://dx.doi.org/10.18632/oncotarget.13270

Ejemplares similares

JAZF1/SUZ12 gene fusion in endometrial stromal sarcomas
por: Hrzenjak, Andelko
Publicado: (2016)

RNA-driven JAZF1-SUZ12 gene fusion in human endometrial stromal cells
por: Gupta, Sachin Kumar, et al.
Publicado: (2021)

JAZF1-SUZ12 dysregulates PRC2 function and gene expression during cell differentiation
por: Tavares, Manuel, et al.
Publicado: (2022)

JAZF1–SUZ12 endometrial stromal sarcoma forming subserosal masses with extraordinary uptake of fluorodeoxyglucose on positron emission tomography: a case report
por: Fujiishi, Koto, et al.
Publicado: (2019)

Live-cell imaging reveals the dynamics of PRC2 and recruitment to chromatin by SUZ12-associated subunits
por: Youmans, Daniel T., et al.
Publicado: (2018)

JAZF1 safeguards human endometrial stromal cells survival and decidualization by repressing the transcription of G0S2
por: Liang, Yingyu, et al.
Publicado: (2023)

A recurrent endometrial stromal sarcoma harbors the novel fusion JAZF1-BCORL1
por: Allen, Allison J, et al.
Publicado: (2017)

Actualización sobre mecanismos de tumorogénesis hipofisaria
por: Cecenarro, Laura Anahi, et al.
Publicado: (2021)

PRC2 is recurrently inactivated through EED or SUZ12 loss in malignant peripheral nerve sheath tumors
por: Lee, William, et al.
Publicado: (2014)

Caenorhabditis elegans MES-3 is a highly divergent ortholog of the canonical PRC2 component SUZ12
por: Snel, Berend, et al.
Publicado: (2022)

CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site
por: Gong, Lihu, et al.
Publicado: (2022)

Accurate H3K27 methylation can be established de novo by SUZ12-directed PRC2
por: Højfeldt, Jonas W, et al.
Publicado: (2018)

Structure and Function of the Polycomb Repressive Complexes PRC1 and PRC2
por: Angrand, Pierre-Olivier
Publicado: (2022)

PRC2 regulates RNA polymerase III transcribed non-translated RNA gene transcription through EZH2 and SUZ12 interaction with TFIIIC complex
por: Liu, Chang, et al.
Publicado: (2015)

RYBP stimulates PRC1 to shape chromatin-based communication between Polycomb repressive complexes
por: Rose, Nathan R, et al.
Publicado: (2016)

Poly(ADP-Ribose) Polymerase 1: Cellular Pluripotency, Reprogramming, and Tumorogenesis
por: Jiang, Bo-Hua, et al.
Publicado: (2015)

TBIO-27. RASOPATHIES AND BRAIN TUMOROGENESIS: ARE SOS1 MUTATIONS ARE CONCERNED?
por: Abdelmoula, Nouha Bouayed, et al.
Publicado: (2020)

A DNA adenine demethylase impairs PRC2-mediated repression of genes marked by a specific chromatin signature
por: Jia, Qingxiao, et al.
Publicado: (2023)

Can COVID-19 induce glioma tumorogenesis through binding cell receptors?
por: Khan, Imran, et al.
Publicado: (2020)

Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops
por: Williamson, Iain, et al.
Publicado: (2023)

Deletion of Jazf1 gene causes early growth retardation and insulin resistance in mice
por: Lee, Hui-Young, et al.
Publicado: (2022)

PCGF1-PRC1 links chromatin repression with DNA replication during hematopoietic cell lineage commitment
por: Takano, Junichiro, et al.
Publicado: (2022)

Activation of automethylated PRC2 by dimerization on chromatin
por: Sauer, Paul V., et al.
Publicado: (2023)

From biomineralization to tumorogenesis—the expanding insight of the physiological and pathological roles of Fam20C
por: Wu, Yanbing, et al.
Publicado: (2021)

Correction: Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops
por: Williamson, Iain, et al.
Publicado: (2023)

PRC2 is dispensable for HOTAIR‐mediated transcriptional repression
por: Portoso, Manuela, et al.
Publicado: (2017)

JAZF1: A metabolic actor subunit of the NuA4/TIP60 chromatin modifying complex
por: Mameri, Amel, et al.
Publicado: (2023)

CTCF-mediated chromatin looping in EGR2 regulation and SUZ12 recruitment critical for peripheral myelination and repair
por: Wang, Jincheng, et al.
Publicado: (2020)

Chromatin regulated interchange between polycomb repressive complex 2 (PRC2)-Ezh2 and PRC2-Ezh1 complexes controls myogenin activation in skeletal muscle cells
por: Stojic, Lovorka, et al.
Publicado: (2011)

The interaction of PRC2 with RNA or chromatin is mutually antagonistic
por: Beltran, Manuel, et al.
Publicado: (2016)

Engaging chromatin: PRC2 structure meets function
por: Chammas, Paul, et al.
Publicado: (2019)

Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration
por: von Schimmelmann, Melanie, et al.
Publicado: (2016)

PRC2 overexpression and PRC2-target gene repression relating to poorer prognosis in small cell lung cancer
por: Sato, Teruyuki, et al.
Publicado: (2013)

High expression of QSOX1 reduces tumorogenesis, and is associated with a better outcome for breast cancer patients
por: Pernodet, Nicolas, et al.
Publicado: (2012)

Not just a writer: PRC2 as a chromatin reader
por: Uckelmann, Michael, et al.
Publicado: (2021)

New insights into the suppression of inflammation and lipid accumulation by JAZF1
por: Chen, Wujun, et al.
Publicado: (2022)

MYCN and PRC1 cooperatively repress docosahexaenoic acid synthesis in neuroblastoma via ELOVL2
por: Ding, Yi, et al.
Publicado: (2019)

Analysis of chromatin accessibility in decidualizing human endometrial stromal cells
por: Vrljicak, Pavle, et al.
Publicado: (2018)

Transcriptional repression by PRC1 in the absence of H2A monoubiquitylation
por: Pengelly, Ana Raquel, et al.
Publicado: (2015)

Mutations and deletions of the SUZ12 polycomb gene in myeloproliferative neoplasms
por: Brecqueville, M, et al.
Publicado: (2011)

Cannot write session to /tmp/vufind_sessions/sess_bau0nqcbk108sbcvag97m5sinm