Paradoxical induction of growth arrest and apoptosis by EGF via the up-regulation of PTEN by activating Redox factor-1/Egr-1 in human lung cancer cells

Epidermal growth factor (EGF) signaling promotes cell proliferation and survival in several types of cancer. Here, however, we showed that EGF inhibits proliferation and promotes programmed cell death in non-small cell lung cancer (NSCLC) cells. In A549 cells, EGF increased redox factor-1 (Ref-1) ex...

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Detalles Bibliográficos
Autores principales: Ryu, Je-won, Choe, Sung Sik, Ryu, Seung-Hee, Park, Eun-Young, Lee, Byoung Wook, Kim, Tae Keun, Ha, Chang Hoon, Lee, Sang-wook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354822/
https://www.ncbi.nlm.nih.gov/pubmed/27935858
http://dx.doi.org/10.18632/oncotarget.13809

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354822/
https://www.ncbi.nlm.nih.gov/pubmed/27935858
http://dx.doi.org/10.18632/oncotarget.13809

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