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The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition

Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we...

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Detalles Bibliográficos
Autores principales: Onofrillo, Carmine, Galbiati, Alice, Montanaro, Lorenzo, Derenzini, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354829/
https://www.ncbi.nlm.nih.gov/pubmed/28032591
http://dx.doi.org/10.18632/oncotarget.13833