The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition

Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we...

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Detalles Bibliográficos
Autores principales: Onofrillo, Carmine, Galbiati, Alice, Montanaro, Lorenzo, Derenzini, Massimo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354829/
https://www.ncbi.nlm.nih.gov/pubmed/28032591
http://dx.doi.org/10.18632/oncotarget.13833
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author Onofrillo, Carmine
Galbiati, Alice
Montanaro, Lorenzo
Derenzini, Massimo
author_facet Onofrillo, Carmine
Galbiati, Alice
Montanaro, Lorenzo
Derenzini, Massimo
author_sort Onofrillo, Carmine
collection PubMed
description Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA.
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spelling pubmed-53548292017-04-24 The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition Onofrillo, Carmine Galbiati, Alice Montanaro, Lorenzo Derenzini, Massimo Oncotarget Research Paper Pre-ribosomal complex RPL5/RPL11/5S rRNA (5S RNP) is considered the central MDM2 inhibitory complex that control p53 stabilization during ribosome biogenesis inhibition. Despite its role is well defined, the dynamic of 5S RNP assembly still requires further characterization. In the present work, we report that MDM2 inhibition is dependent by a pre-existing population of 5S rRNA. Impact Journals LLC 2016-12-09 /pmc/articles/PMC5354829/ /pubmed/28032591 http://dx.doi.org/10.18632/oncotarget.13833 Text en Copyright: © 2017 Onofrillo et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Onofrillo, Carmine
Galbiati, Alice
Montanaro, Lorenzo
Derenzini, Massimo
The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition
title The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition
title_full The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition
title_fullStr The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition
title_full_unstemmed The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition
title_short The pre-existing population of 5S rRNA effects p53 stabilization during ribosome biogenesis inhibition
title_sort pre-existing population of 5s rrna effects p53 stabilization during ribosome biogenesis inhibition
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354829/
https://www.ncbi.nlm.nih.gov/pubmed/28032591
http://dx.doi.org/10.18632/oncotarget.13833
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