An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer

Activating mutations of KRAS are nearly ubiquitous in pancreatic adenocarcinomas occurring in greater than 90% of cases. Cellular transformation by oncogenic RAS requires the RHO guanine exchange factor ARHGEF2 (also known as GEF-H1) for tumor growth and survival. Here, we find oncogenic KRAS activa...

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Detalles Bibliográficos
Autores principales: Kent, Oliver A., Sandí, María-José, Burston, Helen E., Brown, Kevin R., Rottapel, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354848/
https://www.ncbi.nlm.nih.gov/pubmed/27835861
http://dx.doi.org/10.18632/oncotarget.13152

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354848/
https://www.ncbi.nlm.nih.gov/pubmed/27835861
http://dx.doi.org/10.18632/oncotarget.13152

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