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An oncogenic KRAS transcription program activates the RHOGEF ARHGEF2 to mediate transformed phenotypes in pancreatic cancer

Activating mutations of KRAS are nearly ubiquitous in pancreatic adenocarcinomas occurring in greater than 90% of cases. Cellular transformation by oncogenic RAS requires the RHO guanine exchange factor ARHGEF2 (also known as GEF-H1) for tumor growth and survival. Here, we find oncogenic KRAS activa...

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Detalles Bibliográficos
Autores principales:	Kent, Oliver A., Sandí, María-José, Burston, Helen E., Brown, Kevin R., Rottapel, Robert
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354848/ https://www.ncbi.nlm.nih.gov/pubmed/27835861 http://dx.doi.org/10.18632/oncotarget.13152

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