Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model

Interleukin (IL)-12 is a potent antitumor cytokine. However, immunosuppressive tumor microenvironments containing transforming growth factor-β (TGF-β) attenuate cytokine-mediated antitumor immune responses. To enhance the efficacy of IL-12-mediated cancer immunotherapy, decorin (DCN) was explored as...

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Detalles Bibliográficos
Autores principales: Oh, Eonju, Choi, Il-Kyu, Hong, JinWoo, Yun, Chae-Ok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354867/
https://www.ncbi.nlm.nih.gov/pubmed/28002796
http://dx.doi.org/10.18632/oncotarget.13972

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354867/
https://www.ncbi.nlm.nih.gov/pubmed/28002796
http://dx.doi.org/10.18632/oncotarget.13972

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