Cargando…

Oncolytic adenovirus coexpressing interleukin-12 and decorin overcomes Treg-mediated immunosuppression inducing potent antitumor effects in a weakly immunogenic tumor model

Interleukin (IL)-12 is a potent antitumor cytokine. However, immunosuppressive tumor microenvironments containing transforming growth factor-β (TGF-β) attenuate cytokine-mediated antitumor immune responses. To enhance the efficacy of IL-12-mediated cancer immunotherapy, decorin (DCN) was explored as...

Descripción completa

Detalles Bibliográficos
Autores principales:	Oh, Eonju, Choi, Il-Kyu, Hong, JinWoo, Yun, Chae-Ok
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5354867/ https://www.ncbi.nlm.nih.gov/pubmed/28002796 http://dx.doi.org/10.18632/oncotarget.13972

Ejemplares similares

Oncolytic adenovirus coexpressing interleukin-12 and shVEGF restores antitumor immune function and enhances antitumor efficacy
por: Ahn, Hyo Min, et al.
Publicado: (2016)

A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastoma
por: Oh, Eonju, et al.
Publicado: (2018)

Oncolytic Adenovirus Expressing IL-23 and p35 Elicits IFN-γ- and TNF-α-Co-Producing T Cell-Mediated Antitumor Immunity
por: Choi, Il-Kyu, et al.
Publicado: (2013)

Overcoming the limitations of locally administered oncolytic virotherapy
por: Hong, JinWoo, et al.
Publicado: (2019)

Optimizing DC Vaccination by Combination With Oncolytic Adenovirus Coexpressing IL-12 and GM-CSF
por: Zhang, Song-Nan, et al.
Publicado: (2011)

Adenovirus-mediated decorin expression induces cancer cell death through activation of p53 and mitochondrial apoptosis
por: Yoon, A-Rum, et al.
Publicado: (2017)

Hepatocellular carcinoma-targeting oncolytic adenovirus overcomes hypoxic tumor microenvironment and effectively disperses through both central and peripheral tumor regions
por: Yoon, A-Rum, et al.
Publicado: (2018)

A vesicular stomatitis virus glycoprotein epitope-incorporated oncolytic adenovirus overcomes CAR-dependency and shows markedly enhanced cancer cell killing and suppression of tumor growth
por: Yoon, A-Rum, et al.
Publicado: (2015)

ErbB3-Targeting Oncolytic Adenovirus Causes Potent Tumor Suppression by Induction of Apoptosis in Cancer Cells
por: Jung, Bo-Kyeong, et al.
Publicado: (2022)

Challenges and progress toward tumor-targeted therapy by systemic delivery of polymer-complexed oncolytic adenoviruses
por: Thambi, Thavasyappan, et al.
Publicado: (2022)

Oncolytic adenovirus-mediated expression of decorin facilitates CAIX-targeting CAR-T therapy against renal cell carcinoma
por: Zhang, Chen, et al.
Publicado: (2021)

The systemic delivery of an oncolytic adenovirus expressing decorin inhibits bone metastasis in a mouse model of human prostate cancer
por: Xu, Weidong, et al.
Publicado: (2014)

Adenovirus expressing dual c-Met-specific shRNA exhibits potent antitumor effect through autophagic cell death accompanied by senescence-like phenotypes in glioblastoma cells
por: Lee, Jung-Sun, et al.
Publicado: (2015)

Safety Profiles and Antitumor Efficacy of Oncolytic Adenovirus Coated with Bioreducible Polymer in the Treatment of a CAR Negative Tumor Model
por: Jung, Soo-Jung, et al.
Publicado: (2014)

Therapeutic effects of mesenchymal stem cells loaded with oncolytic adenovirus carrying decorin on a breast cancer lung metastatic mouse model
por: Zhang, Yuning, et al.
Publicado: (2022)

Potent antitumor efficacy of human dental pulp stem cells armed with YSCH-01 oncolytic adenovirus
por: He, Xu, et al.
Publicado: (2023)

Mesenchymal stem cells used as carrier cells of oncolytic adenovirus results in enhanced oncolytic virotherapy
por: Mahasa, Khaphetsi Joseph, et al.
Publicado: (2020)

Potent antitumor activity of oncolytic adenovirus expressing Beclin-1 via induction of autophagic cell death in leukemia
por: Tong, Yin, et al.
Publicado: (2013)

Combined therapy with oncolytic adenoviruses encoding TRAIL and IL-12 genes markedly suppressed human hepatocellular carcinoma both in vitro and in an orthotopic transplanted mouse model
por: El-Shemi, Adel Galal, et al.
Publicado: (2016)

The effects of radiation on antitumor efficacy of an oncolytic adenovirus vector in the Syrian hamster model
por: Young, Brittany A., et al.
Publicado: (2013)

Combined Treatment with an Oncolytic Adenovirus and Antitumor Activity of Vincristine against Retinoblastoma Cells
por: Song, Xin, et al.
Publicado: (2012)

Bifidobacterium affects antitumor efficacy of oncolytic adenovirus in a mouse model of melanoma
por: Tripodi, Lorella, et al.
Publicado: (2023)

Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect)
por: Oh, Eonju, et al.
Publicado: (2019)

Efficient antitumor effects of a novel oncolytic adenovirus fully composed of species B adenovirus serotype 35
por: Ono, Ryosuke, et al.
Publicado: (2021)

Oncolytic adenoviruses: A potent form of tumor immunovirotherapy
por: Cerullo, Vincenzo, et al.
Publicado: (2012)

Regulatory T Cells Induce Metastasis by Activating Tgf-Β and Enhancing the Epithelial–Mesenchymal Transition
por: Oh, Eonju, et al.
Publicado: (2019)

Erratum to: Combined therapy with oncolytic adenoviruses encoding TRAIL and IL-12 genes markedly suppressed human hepatocellular carcinoma both in vitro and in an orthotopic transplanted mouse model
por: El-Shemi, Adel Galal, et al.
Publicado: (2016)

Relaxin-expressing oncolytic adenovirus induces remodeling of physical and immunological aspects of cold tumor to potentiate PD-1 blockade
por: Jung, Bo-Kyeong, et al.
Publicado: (2020)

An oncolytic virus–delivered TGFβ inhibitor overcomes the immunosuppressive tumor microenvironment
por: DePeaux, Kristin, et al.
Publicado: (2023)

A novel Golgi protein (GOLPH2)-regulated oncolytic adenovirus exhibits potent antitumor efficacy in hepatocellular carcinoma
por: Wang, Yigang, et al.
Publicado: (2015)

A Triple-Regulated Oncolytic Adenovirus Carrying MicroRNA-143 Exhibits Potent Antitumor Efficacy in Colorectal Cancer
por: Luo, Qifeng, et al.
Publicado: (2020)

Combination of autophagy inducer rapamycin and oncolytic adenovirus improves antitumor effect in cancer cells
por: Cheng, Pei-Hsin, et al.
Publicado: (2013)

Oncolytic adenovirus expressing interleukin-18 improves antitumor activity of dacarbazine for malignant melanoma
por: Yang, Chunhua, et al.
Publicado: (2016)

Strong antitumor efficacy of a pancreatic tumor‐targeting oncolytic adenovirus for neuroendocrine tumors
por: Yamamoto, Yuki, et al.
Publicado: (2017)

Erratum: Oh, E., et al. Cryopreserved Human Natural Killer Cells Exhibit Potent Antitumor Efficacy against Orthotopic Pancreatic Cancer through Efficient Tumor-Homing and Cytolytic Ability (Running Title: Cryopreserved NK Cells Exhibit Antitumor Effect). Cancers 2019, 11, 966
por: Oh, Eonju, et al.
Publicado: (2020)

Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene
por: Zhou, Xiumei, et al.
Publicado: (2012)

Oncolytic Viruses and Immune Checkpoint Inhibitors: Preclinical Developments to Clinical Trials
por: Hwang, June Kyu, et al.
Publicado: (2020)

Systemic Administration and Targeted Delivery of Immunogenic Oncolytic Adenovirus Encapsulated in Extracellular Vesicles for Cancer Therapies
por: Garofalo, Mariangela, et al.
Publicado: (2018)

Oncolytic Adenoviruses in Gastrointestinal Cancers
por: Yokoda, Raquel T., et al.
Publicado: (2018)

Oncolytic Adenoviruses in Cancer Treatment
por: Alemany, Ramon
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ksumnrv60un48g18tp3r01i1hm