Amplification of ACK1 promotes gastric tumorigenesis via ECD-dependent p53 ubiquitination degradation

Amplification or over-expression of an activated Cdc42-associated kinase 1 (ACK1) gene is common in breast, lung and ovarian cancers. However, little is known about the role of ACK1 in gastric tumorigenesis. Here, we found that DNA copy numbers of the ACK1 gene and its mRNA expression levels were si...

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Detalles Bibliográficos
Autores principales: Xu, Song-Hui, Huang, Jin-Zhou, Chen, Min, Zeng, Ming, Zou, Fei-Yan, Chen, De, Yan, Guang-Rong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2015
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355047/
https://www.ncbi.nlm.nih.gov/pubmed/26498357
http://dx.doi.org/10.18632/oncotarget.6194

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355047/
https://www.ncbi.nlm.nih.gov/pubmed/26498357
http://dx.doi.org/10.18632/oncotarget.6194

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