Mitotic catastrophe and cell cycle arrest are alternative cell death pathways executed by bortezomib in rituximab resistant B-cell lymphoma cells

The ubiqutin-proteasome system (UPS) plays a role in rituximab-chemotherapy resistance and bortezomib (BTZ) possesses caspase-dependent (i.e. Bak stabilization) and a less characterized caspase–independent mechanism-of-action(s). Here, we define BTZ-induced caspase-independent cell death pathways. A...

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Detalles Bibliográficos
Autores principales: Gu, Juan J., Kaufman, Gregory P., Mavis, Cory, Czuczman, Myron S, Hernand ez-Ilizaliturri, Francisco J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355050/
https://www.ncbi.nlm.nih.gov/pubmed/28055975
http://dx.doi.org/10.18632/oncotarget.14405

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355050/
https://www.ncbi.nlm.nih.gov/pubmed/28055975
http://dx.doi.org/10.18632/oncotarget.14405

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