AML associated oncofusion proteins PML-RARA, AML1-ETO and CBFB-MYH11 target RUNX/ETS-factor binding sites to modulate H3ac levels and drive leukemogenesis

Chromosomal translocations are one of the hallmarks of acute myeloid leukemia (AML), often leading to gene fusions and expression of an oncofusion protein. Over recent years it has become clear that most of the AML associated oncofusion proteins molecularly adopt distinct mechanisms for inducing leu...

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Detalles Bibliográficos
Autores principales: Singh, Abhishek A., Mandoli, Amit, Prange, Koen H.M., Laakso, Marko, Martens, Joost H.A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355061/
https://www.ncbi.nlm.nih.gov/pubmed/28030795
http://dx.doi.org/10.18632/oncotarget.14150

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355061/
https://www.ncbi.nlm.nih.gov/pubmed/28030795
http://dx.doi.org/10.18632/oncotarget.14150

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