Otub1 stabilizes MDMX and promotes its proapoptotic function at the mitochondria

Otub1 regulates p53 stability and activity via non-canonical inhibition of UbcH5, the MDM2 cognate ubiquitin-conjugating enzyme (E2). However, whether Otub1 regulates MDMX stability and activity is not clear. Here we report that Otub1 also suppresses MDM2-mediated MDMX ubiquitination in cells and in...

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Detalles Bibliográficos
Autores principales: Chen, Yingxiao, Wang, Yue-Gang, Li, Yuhuang, Sun, Xiao-Xin, Dai, Mu-Shui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355245/
https://www.ncbi.nlm.nih.gov/pubmed/28035068
http://dx.doi.org/10.18632/oncotarget.14278

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355245/
https://www.ncbi.nlm.nih.gov/pubmed/28035068
http://dx.doi.org/10.18632/oncotarget.14278

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