Tumor cell migration is inhibited by a novel therapeutic strategy antagonizing the alpha-7 receptor

A 14mer peptide (T14) derived from the C-terminus of acetylcholinesterase (AChE) selectively activates metastatic breast cancer cells via the alpha-7 nicotinic receptor (α7 nAChR). This naturally occurring peptide is also present in brain, is elevated in Alzheimer's disease, and is antagonised...

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Detalles Bibliográficos
Autores principales: Pepper, Chris, Tu, Henry, Morrill, Paul, Garcia-Rates, Sara, Fegan, Chris, Greenfield, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355275/
https://www.ncbi.nlm.nih.gov/pubmed/28077796
http://dx.doi.org/10.18632/oncotarget.14545

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355275/
https://www.ncbi.nlm.nih.gov/pubmed/28077796
http://dx.doi.org/10.18632/oncotarget.14545

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