Enhancement of the bioavailability of a novel anticancer compound (acetyltanshinone IIA) by encapsulation within mPEG-PLGA nanoparticles: a study of formulation optimization, toxicity, and pharmacokinetics

The Poly (ethylene glycol) methyl ether-block-poly (lactide-co-glycolide) (mPEG-PLGA) nanoparticles carrying acetyltanshinone IIA (ATA), a novel anti-breast cancer agent, were prepared by ultrasonic emulsion method to enhance the bioavailability and reduce the toxicity. Systematic optimization of en...

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Detalles Bibliográficos
Autores principales: Wang, Qi, Wei, Na, Liu, Xiaofeng, Chang, Alex, Luo, Kathy Qian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355322/
https://www.ncbi.nlm.nih.gov/pubmed/28061455
http://dx.doi.org/10.18632/oncotarget.14481

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355322/
https://www.ncbi.nlm.nih.gov/pubmed/28061455
http://dx.doi.org/10.18632/oncotarget.14481

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