ABL2 suppresses FLT3-ITD-induced cell proliferation through negative regulation of AKT signaling

The type III receptor tyrosine kinase FLT3 is one of the most commonly mutated oncogenes in acute myeloid leukemia (AML). Inhibition of mutated FLT3 in combination with chemotherapy has displayed promising results in clinical trials. However, one of the major obstacles in targeting FLT3 is the devel...

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Detalles Bibliográficos
Autores principales: Kazi, Julhash U., Rupar, Kaja, Marhäll, Alissa, Moharram, Sausan A., Khanum, Fatima, Shah, Kinjal, Gazi, Mohiuddin, Nagaraj, Sachin Raj M., Sun, Jianmin, Chougule, Rohit A., Rönnstrand, Lars
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355336/
https://www.ncbi.nlm.nih.gov/pubmed/28086240
http://dx.doi.org/10.18632/oncotarget.14577

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355336/
https://www.ncbi.nlm.nih.gov/pubmed/28086240
http://dx.doi.org/10.18632/oncotarget.14577

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