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Saposin C promotes survival and prevents apoptosis via PI3K/Akt-dependent pathway in prostate cancer cells

BACKGROUND: In addition to androgens, growth factors are also implicated in the development and neoplastic growth of the prostate gland. Prosaposin is a potent neurotrophic molecule. Homozygous inactivation of prosaposin in mice has led to the development of a number of abnormalities in the male rep...

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Detalles Bibliográficos
Autores principales: Lee, Tae-Jin, Sartor, Oliver, Luftig, Ronald B, Koochekpour, Shahriar
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC535542/
https://www.ncbi.nlm.nih.gov/pubmed/15548330
http://dx.doi.org/10.1186/1476-4598-3-31