Development and characterization of methoxy poly(ethylene oxide)-block-poly(ε-caprolactone) (PEO-b-PCL) micelles as vehicles for the solubilization and delivery of tacrolimus

Tacrolimus is a potent immunosuppressant; however, it suffers from several problems such as poor water solubility (4–12 μg/mL), low and variable oral bioavailability in patients, and narrow therapeutic window that could not be solved by the currently available i.v. formulation (Prograf®). Moreover,...

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Detalles Bibliográficos
Autores principales: Ali, Raisuddin, Farah, Abubakar, Binkhathlan, Ziyad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355555/
https://www.ncbi.nlm.nih.gov/pubmed/28344477
http://dx.doi.org/10.1016/j.jsps.2016.06.009

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355555/
https://www.ncbi.nlm.nih.gov/pubmed/28344477
http://dx.doi.org/10.1016/j.jsps.2016.06.009

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