GATA6 Plays an Important Role in the Induction of Human Definitive Endoderm, Development of the Pancreas, and Functionality of Pancreatic β Cells

Induced pluripotent stem cells were created from a pancreas agenesis patient with a mutation in GATA6. Using genome-editing technology, additional stem cell lines with mutations in both GATA6 alleles were generated and demonstrated a severe block in definitive endoderm induction, which could be resc...

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Detalles Bibliográficos
Autores principales: Tiyaboonchai, Amita, Cardenas-Diaz, Fabian L., Ying, Lei, Maguire, Jean Ann, Sim, Xiuli, Jobaliya, Chintan, Gagne, Alyssa L., Kishore, Siddharth, Stanescu, Diana E., Hughes, Nkecha, De Leon, Diva D., French, Deborah L., Gadue, Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355564/
https://www.ncbi.nlm.nih.gov/pubmed/28196690
http://dx.doi.org/10.1016/j.stemcr.2016.12.026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355564/
https://www.ncbi.nlm.nih.gov/pubmed/28196690
http://dx.doi.org/10.1016/j.stemcr.2016.12.026

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