Glycosylation of the Hemagglutinin Protein of H5N1 Influenza Virus Increases Its Virulence in Mice by Exacerbating the Host Immune Response

The highly pathogenic avian influenza (HPAI) H5N1 viruses continue to circulate in nature and threaten public health. Although several viral determinants and host factors that influence the virulence of HPAI H5N1 viruses in mammals have been identified, the detailed molecular mechanism remains poorl...

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Detalles Bibliográficos
Autores principales: Zhao, Dongming, Liang, Libin, Wang, Shuai, Nakao, Tomomi, Li, Yanbing, Liu, Liling, Guan, Yuntao, Fukuyama, Satoshi, Bu, Zhigao, Kawaoka, Yoshihiro, Chen, Hualan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2017
Materias:
Pathogenesis and Immunity
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355609/
https://www.ncbi.nlm.nih.gov/pubmed/28100622
http://dx.doi.org/10.1128/JVI.02215-16

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355609/
https://www.ncbi.nlm.nih.gov/pubmed/28100622
http://dx.doi.org/10.1128/JVI.02215-16

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