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Efficient Precision Genome Editing in iPSCs via Genetic Co-targeting with Selection
Genome editing in induced pluripotent stem cells is currently hampered by the laborious and expensive nature of identifying homology-directed repair (HDR)-modified cells. We present an approach where isolation of cells bearing a selectable, HDR-mediated editing event at one locus enriches for HDR-me...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355643/ https://www.ncbi.nlm.nih.gov/pubmed/28238794 http://dx.doi.org/10.1016/j.stemcr.2017.01.021 |