Pre-plaque conformational changes in Alzheimer's disease-linked Aβ and APP

Reducing levels of the aggregation-prone Aβ peptide that accumulates in the brain with Alzheimer's disease (AD) has been a major target of experimental therapies. An alternative approach may be to stabilize the physiological conformation of Aβ. To date, the physiological state of Aβ in brain re...

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Detalles Bibliográficos
Autores principales: Klementieva, O., Willén, K., Martinsson, I., Israelsson, B., Engdahl, A., Cladera, J., Uvdal, P., Gouras, G. K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355803/
https://www.ncbi.nlm.nih.gov/pubmed/28287086
http://dx.doi.org/10.1038/ncomms14726

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355803/
https://www.ncbi.nlm.nih.gov/pubmed/28287086
http://dx.doi.org/10.1038/ncomms14726

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