Antiangiogenic platinum through glycan targeting

Heparan sulfate is identified as a ligand receptor for polynuclear platinum anti-cancer agents through sulfate cluster binding. We present a new biological role for platinum and coordination compounds and a new target for metal-based drugs while presenting a new chemotype for heparanase and growth f...

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Detalles Bibliográficos
Autores principales: Peterson, Erica J., Daniel, A. Gerard, Katner, Samantha J., Bohlmann, Lisa, Chang, Chih-Wei, Bezos, Anna, Parish, Christopher R., von Itzstein, Mark, Berners-Price, Susan J., Farrell, Nicholas P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355868/
https://www.ncbi.nlm.nih.gov/pubmed/28451171
http://dx.doi.org/10.1039/c6sc02515c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355868/
https://www.ncbi.nlm.nih.gov/pubmed/28451171
http://dx.doi.org/10.1039/c6sc02515c

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