The development of novel LTA(4)H modulators to selectively target LTB(4) generation

The pro-inflammatory mediator leukotriene B(4) (LTB(4)) is implicated in the pathologies of an array of diseases and thus represents an attractive therapeutic target. The enzyme leukotriene A(4) hydrolase (LTA(4)H) catalyses the distal step in LTB(4) synthesis and hence inhibitors of this enzyme hav...

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Detalles Bibliográficos
Autores principales: Low, Caroline M., Akthar, Samia, Patel, Dhiren F., Löser, Stephan, Wong, Chi-Tung, Jackson, Patricia L., Blalock, J. Edwin, Hare, Stephen A., Lloyd, Clare M., Snelgrove, Robert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355877/
https://www.ncbi.nlm.nih.gov/pubmed/28303931
http://dx.doi.org/10.1038/srep44449

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355877/
https://www.ncbi.nlm.nih.gov/pubmed/28303931
http://dx.doi.org/10.1038/srep44449

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