Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

In retinitis pigmentosa, loss of cone photoreceptors leads to blindness, and preservation of cone function is a major therapeutic goal. However, cone loss is thought to occur as a secondary event resulting from degeneration of rod photoreceptors. Here we report a genome editing approach in which ade...

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Detalles Bibliográficos
Autores principales: Yu, Wenhan, Mookherjee, Suddhasil, Chaitankar, Vijender, Hiriyanna, Suja, Kim, Jung-Woong, Brooks, Matthew, Ataeijannati, Yasaman, Sun, Xun, Dong, Lijin, Li, Tiansen, Swaroop, Anand, Wu, Zhijian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355895/
https://www.ncbi.nlm.nih.gov/pubmed/28291770
http://dx.doi.org/10.1038/ncomms14716

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355895/
https://www.ncbi.nlm.nih.gov/pubmed/28291770
http://dx.doi.org/10.1038/ncomms14716

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