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Directed Evolution of Key Residues in Fluorescent Protein Inverses the Polarity of Voltage Sensitivity in the Genetically Encoded Indicator ArcLight
[Image: see text] Genetically encoded calcium indicators (GECIs) produce unprecedentedly large signals that have enabled routine optical recording of single neuron activity in vivo in rodent brain. Genetically encoded voltage indicators (GEVIs) offer a more direct measure of neuronal electrical stat...
Autores principales: | Platisa, Jelena, Vasan, Ganesh, Yang, Amy, Pieribone, Vincent A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical
Society
2017
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355904/ https://www.ncbi.nlm.nih.gov/pubmed/28045247 http://dx.doi.org/10.1021/acschemneuro.6b00234 |
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