Specific inhibition of CK2α from an anchor outside the active site

The development of selective inhibitors of protein kinases is challenging because of the significant conservation of the ATP binding site. Here, we describe a new mechanism by which the protein kinase CK2α can be selectively inhibited using features outside the ATP site. We have identified a new bin...

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Detalles Bibliográficos
Autores principales: Brear, Paul, De Fusco, Claudia, Hadje Georgiou, Kathy, Francis-Newton, Nicola J., Stubbs, Christopher J., Sore, Hannah F., Venkitaraman, Ashok R., Abell, Chris, Spring, David R., Hyvönen, Marko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2016
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355960/
https://www.ncbi.nlm.nih.gov/pubmed/28451126
http://dx.doi.org/10.1039/c6sc02335e

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355960/
https://www.ncbi.nlm.nih.gov/pubmed/28451126
http://dx.doi.org/10.1039/c6sc02335e

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