A Study on CYP2C19 and CYP2D6 Polymorphic Effects on Pharmacokinetics and Pharmacodynamics of Amitriptyline in Healthy Koreans

We performed a double‐blinded, genotype‐based stratification study to explore the pharmacokinetics and pharmacodynamics of amitriptyline according to CYP2C19 and CYP2D6 genotype in Korean subjects. Twenty‐four healthy adults were grouped by genotype of CYP2C19 and CYP2D6. After a single dose of 25 m...

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Detalles Bibliográficos
Autores principales: Ryu, S, Park, S, Lee, JH, Kim, YR, Na, HS, Lim, HS, Choi, HY, Hwang, IY, Lee, JG, Park, ZW, Oh, WY, Kim, JM, Choi, SE
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355968/
https://www.ncbi.nlm.nih.gov/pubmed/28296334
http://dx.doi.org/10.1111/cts.12451

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355968/
https://www.ncbi.nlm.nih.gov/pubmed/28296334
http://dx.doi.org/10.1111/cts.12451

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