Identification of the metabolic alterations associated with the multidrug resistant phenotype in cancer and their intercellular transfer mediated by extracellular vesicles

Multidrug resistance (MDR) is a serious obstacle to efficient cancer treatment. Overexpression of P-glycoprotein (P-gp) plays a significant role in MDR. Recent studies proved that targeting cellular metabolism could sensitize MDR cells. In addition, metabolic alterations could affect the extracellul...

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Detalles Bibliográficos
Autores principales: Lopes-Rodrigues, Vanessa, Di Luca, Alessio, Mleczko, Justyna, Meleady, Paula, Henry, Michael, Pesic, Milica, Cabrera, Diana, van Liempd, Sebastiaan, Lima, Raquel T., O’Connor, Robert, Falcon-Perez, Juan M., Vasconcelos, M. Helena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356019/
https://www.ncbi.nlm.nih.gov/pubmed/28303926
http://dx.doi.org/10.1038/srep44541

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356019/
https://www.ncbi.nlm.nih.gov/pubmed/28303926
http://dx.doi.org/10.1038/srep44541

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