Implications of evolutionary engineering for growth and recombinant protein production in methanol-based growth media in the yeast Pichia pastoris

BACKGROUND: Pichia pastoris is a widely used eukaryotic expression host for recombinant protein production. Adaptive laboratory evolution (ALE) has been applied in a wide range of studies in order to improve strains for biotechnological purposes. In this context, the impact of long-term carbon sourc...

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Detalles Bibliográficos
Autores principales: Moser, Josef W., Prielhofer, Roland, Gerner, Samuel M., Graf, Alexandra B., Wilson, Iain B. H., Mattanovich, Diethard, Dragosits, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356285/
https://www.ncbi.nlm.nih.gov/pubmed/28302114
http://dx.doi.org/10.1186/s12934-017-0661-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356285/
https://www.ncbi.nlm.nih.gov/pubmed/28302114
http://dx.doi.org/10.1186/s12934-017-0661-5

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