Structural, mechanistic and functional insight into gliotoxin bis-thiomethylation in Aspergillus fumigatus

Gliotoxin is an epipolythiodioxopiperazine (ETP) class toxin, contains a disulfide bridge that mediates its toxic effects via redox cycling and is produced by the opportunistic fungal pathogen Aspergillus fumigatus. Self-resistance against gliotoxin is effected by the gliotoxin oxidase GliT, and att...

Descripción completa

Detalles Bibliográficos
Autores principales: Dolan, Stephen K., Bock, Tobias, Hering, Vanessa, Owens, Rebecca A., Jones, Gary W., Blankenfeldt, Wulf, Doyle, Sean
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society 2017
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356443/
https://www.ncbi.nlm.nih.gov/pubmed/28179499
http://dx.doi.org/10.1098/rsob.160292

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356443/
https://www.ncbi.nlm.nih.gov/pubmed/28179499
http://dx.doi.org/10.1098/rsob.160292

Ejemplares similares