Ultra-specific discrimination of single-nucleotide mutations using sequestration-assisted molecular beacons

Reliably distinguishing single-nucleotide mutations (SNMs) at low abundance is of great significance in clinical diagnosis. However, the specificity of most current SNM discrimination methods based on the Watson–Crick hybridization is seriously limited by the cross-reactivity of the probe with close...

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Detalles Bibliográficos
Autores principales: Hu, Shichao, Tang, Wei, Zhao, Yan, Li, Na, Liu, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356502/
https://www.ncbi.nlm.nih.gov/pubmed/28451240
http://dx.doi.org/10.1039/c6sc03048c

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5356502/
https://www.ncbi.nlm.nih.gov/pubmed/28451240
http://dx.doi.org/10.1039/c6sc03048c

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